Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Erratum for "Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats"

Sarawoot Palipoch¹ , Phanit Koomhin¹, Chuchard Punsawad¹, Prasit Suwannalert²

¹School of Medicine, Walailak University, 222 Thaiburi, Thasala District, Nakhon Si Thammarat, 80161; ²Department of Pathobiology, Faculty of Science, Mahidol University, 272 Rama VI Road, Ratchathewi District, Bangkok 10400, Thailand.

For correspondence:- Sarawoot Palipoch Email: sarawoot.pa@wu.ac.th Tel:+6675672873

Accepted: 14 March 2019 Published: 31 May 2019

Citation: Palipoch S, Koomhin P, Punsawad C, Suwannalert P. Erratum for "Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats". Trop J Pharm Res 2019; 18(5):1149-1149 doi: 10.4314/tjpr.v18i5.33

© 2019 The authors.
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Abstract

Erratum

Palipoch et al Trop J Pharm Res 2019, 18(4): 823-828 http://dx.doi.org/10.4314/tjpr.v18i4.20

A wrong abstract was inadvertently published in the above article. This error is highly regretted. The correct abstract is published below.

Abstract

Purpose: To investigate the antioxidant and anti-inflammatory effects of aqueous leaf extract of T. laurifolia against alcoholic liver injury in rats.

Methods: Male Wistar rats were administered either normal saline, ethanol (EtOH), normal saline with low or high dose T. laurifolia leaf extract (TL-LD or TL-HD), EtOH with TL-LD or EtOH with TL-HD. Blood biochemical indices: hepatic malondialdehyde (MDA) levels, liver histopathology, hepatic cytochrome P450 2E1 (CYP2E1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and pro-inflammatory cytokines, including interleukin 1 beta (IL-1β) and tumor necrotic factor alpha (TNF-α) mRNA expressions, were determined using standard methods.

Results: The leaf extract of T. Laurifolia decreased hepatic MDA levels, improved liver pathology and down-regulated mRNA expressions of CYP2E1, NADPH oxidase and pro-inflammatory cytokinesin ethanol-treated rats.

Conclusion: These results demonstrate that aqueous extract of T. Laurifolia exerts hepatoprotective effect against alcoholic liver injury through a mechanism involving inhibition of oxidative stress and inflammation.

Citation: Palipoch S, Koomhin P, Punsawad C, Suwannalert P. Effect of aqueous leaf extract of Thunbergia laurifolia on alcohol-induced liver injury in rats. Trop J Pharm Res 2019; 18(4):823-828 Erratum: 2019; 18(5):911-912 http://dx.doi.org/10.4314/tjpr.v18i5.33

Keywords: Thunbergia laurifolia, Alcohol, Liver injury, Oxidative stress, inflammation, Protection